JWH-030是一种研究性化学品,是大麻素受体激动剂。[1]它具有镇痛作用,用于科学研究。[2]它是CB1受体的部分激动剂,Ki为87 nM,大约是THC效力的一半。[3]它被发现并以约翰·威廉·霍夫曼的名字命名。
在美国,3-(1-萘甲酰基)吡咯类CB1受体激动剂(例如JWH-030)属于附表I管制物质。[4]
- ^ Lainton JA, Huffman JW, Martin BR, Compton DR. 1-Alkyl-3-(1-naphthoyl) pyrroles: A new class of cannabinoid.. Tetrahedron Letters. February 1995, 36 (9): 1401–4. doi:10.1016/0040-4039(95)00016-6.
- ^ Pertwee RG, Griffin G, Lainton JA, Huffman JW. Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens. European Journal of Pharmacology. September 1995, 284 (3): 241–7. PMID 8666005. doi:10.1016/0014-2999(95)00318-f.
- ^ Griffin G, Atkinson PJ, Showalter VM, Martin BR, Abood ME. Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes. The Journal of Pharmacology and Experimental Therapeutics. May 1998, 285 (2): 553–60. PMID 9580597.
- ^ 美国法典第21编 § 第812节:Schedules of controlled substances